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KMID : 0861020130280060001
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Korea Journal of Herbology
2013 Volume.28 No. 6 p.1 ~ p.7
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Kang Seok-Yong
Oh Tae-Woo
Kim Jin-Woong
Park Yong-Ki
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Abstract
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Objectives: The root of Peucedanum japonicum Thunberg (Peucedani Japonici Radix; PJR) has been traditionally used as an herbal medicine for the treatment of anti-headache, anti-paralysis, anti-cancer, vascular protection, and blood pressure regulation. In this study, we investigated the anti-allergic effect of PJR water extract on ovalbumin (OVA)-induced allergic asthma in mice.
Methods : Mice were sensitized at days 1, 8 and 15 with OVA and airway challenged at days 22, 24, 26, 28, and 30 to induced allergic asthma. PJR-W extract at doses of 100 and 300 ㎎/㎏/body weight (bw) was orally administered during OVA challenge once per a day. The levels of allergic mediators such as immunoglobulin (Ig) E, and Th1/Th2 cytokines (IFN-γ and IL-4) were measured in the sera of mice by ELISA. The histological change of lung tissue was observed with hematoxylin and eosin (H&E) staining.
Results : The administration of PJR-W extract significantly decreased the serum levels of IgE, IL-4, and IFN-γ compared with those of OVA control group. In H&E staining, PJR-E extract inhibited OVA-induced airway inflammation and the inflammatory cells infiltration in the peribronchial regions of the lung.
Conclusions : These results indicate that PJR-W extract has an anti-inflammatory and anti-allergic effect on allergic response through the down-regulation of allergic mediators, suggesting that this herb may be used as a useful source for the treatment of allergic inflammatory diseases such as asthma.
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KEYWORD
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Peucedani Japonici Radix, Peucedanum japonicum Thunberg, ovalbumin, allergic response, inflammation, asthma
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